Difluoromethanesulfonyl chloride, with CAS number 1512-30-7, is a high-reactivity fluorinating reagent. It is widely employed in medicinal chemistry for the introduction of difluoromethyl (-CF2H) and difluoromethanesulfonyl (-SO2CF2H) groups, which serve as bioisosteres to enhance metabolic stability and lipophilicity. As a professional supplier, we provide this moisture-sensitive product in specialized packaging to ensure safety and quality stability during transport and storage.
Product Name :
Difluoromethanesulfonyl chlorideCAS No. :
1512-30-7Application :
organic synthesis intermediate
Properties
Product: Difluoromethanesulfonyl chloride
CAS: 1512-30-7
Molecular Formula:CHCIF202S
Molecular Weight:172.68 g/mol
Appearance:Colorless transparent liquid
Boiling Point:108-110 °C (lit.)
Refractive index:n20/D 1.385(lit.)
Density:1.610 g/mL at 25 °C (lit.)
Solubility:Soluble in aprotic organic solvents such as dichloromethane, chloroform, and diethyl ether.
Specification
| Items | Specifications |
| Appearance | Colorless transparent liquid |
| Purity | 99.2%min |
Applications
DUDLEY’s Difluoromethanesulfonyl chloride (CAS: 1512-30-7) is a highly valuable "magic reagent" in organofluorine chemistry, mainly used to improve the properties of bioactive molecules.
1. Drug Discovery:Difluoromethylating agents: Under photoredox catalysis or free radical reaction conditions, sulfur dioxide can be removed to directly introduce difluoromethyl (-CF2H) into aromatic or heterocyclic rings. The -CF2H group is often considered a bioisostere of hydroxyl (-OH) or thiol (-SH), which can significantly enhance the lipophilicity and metabolic stability of drugs ("fluorine effect").
2. Organic Synthesis : Difluoromethanesulfonate synthesis: Reaction with alcohols yields difluoromethanesulfonates, a high-performance leaving group used in subsequent substitution reactions.
Difluoromethanesulfonamide synthesis: Reaction with amines yields difluoromethanesulfonamides, an active structural unit in many pesticide and pharmaceutical molecules.
3. Agricultural chemicals:Used in the development of fluorinated herbicides or insecticides with novel mechanisms of action.
Package


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