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Difluoromethanesulfonyl chloride CAS: 1512-30-7

Difluoromethanesulfonyl chloride CAS: 1512-30-7

Difluoromethanesulfonyl chloride, with CAS number 1512-30-7, is a high-reactivity fluorinating reagent. It is widely employed in medicinal chemistry for the introduction of difluoromethyl (-CF2H) and difluoromethanesulfonyl (-SO2CF2H) groups, which serve as bioisosteres to enhance metabolic stability and lipophilicity. As a professional supplier, we provide this moisture-sensitive product in specialized packaging to ensure safety and quality stability during transport and storage.

  • Product Name :

    Difluoromethanesulfonyl chloride
  • CAS No. :

    1512-30-7
  • Application :

    organic synthesis intermediate
  • Description
Our difluoromethanesulfonyl chloride is a colorless to pale yellow fuming liquid and a potent fluorinated sulfonating agent. It is an important tool in medicinal chemistry for introducing difluoromethyl (-CF2H), a lipophilic hydrogen bond donor, and is often used to regulate the metabolic stability and membrane permeability of drug molecules. We employ advanced chlorination processes and strictly control the anhydrous production environment to ensure high product purity and low acid impurities, enabling us to provide high-quality fluorinated building blocks to pharmaceutical and pesticide research institutions worldwide.

 

 

Properties

Product: Difluoromethanesulfonyl chloride

CAS:  1512-30-7

Molecular Formula:CHCIF202S

Molecular Weight:172.68 g/mol

Appearance:Colorless transparent liquid

Boiling Point:108-110 °C (lit.)

Refractive index:n20/D 1.385(lit.)

Density:1.610 g/mL at 25 °C (lit.)

Solubility:Soluble in aprotic organic solvents such as dichloromethane, chloroform, and diethyl ether.

 

Specification

Items Specifications
Appearance Colorless transparent liquid
Purity 99.2%min

 

Applications

DUDLEY’s Difluoromethanesulfonyl chloride (CAS: 1512-30-7) is a highly valuable "magic reagent" in organofluorine chemistry, mainly used to improve the properties of bioactive molecules.

1. Drug Discovery:Difluoromethylating agents: Under photoredox catalysis or free radical reaction conditions, sulfur dioxide can be removed to directly introduce difluoromethyl (-CF2H) into aromatic or heterocyclic rings. The -CF2H group is often considered a bioisostere of hydroxyl (-OH) or thiol (-SH), which can significantly enhance the lipophilicity and metabolic stability of drugs ("fluorine effect").

     

2. Organic Synthesis : Difluoromethanesulfonate synthesis: Reaction with alcohols yields difluoromethanesulfonates, a high-performance leaving group used in subsequent substitution reactions.

 

Difluoromethanesulfonamide synthesis: Reaction with amines yields difluoromethanesulfonamides, an active structural unit in many pesticide and pharmaceutical molecules.

 

3. Agricultural chemicals:Used in the development of fluorinated herbicides or insecticides with novel mechanisms of action.    

 

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