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3,4-Difluoro-2-methoxyphenylacetic acid CAS:1558274-26-2

3,4-Difluoro-2-methoxyphenylacetic acid CAS:1558274-26-2

3,4-Difluoro-2-methoxyphenylacetic acid, with CAS number 1558274-26-2, is a high-purity fluorinated phenylacetic acid derivative. It is widely recognized as a critical strategic intermediate for the synthesis of next-generation non-opioid analgesics, specifically NaV1.8 inhibitors like Suzetrigine (VX-548). As a professional supplier, we ensure strict impurity control and consistent quality to support global pharmaceutical R&D and clinical trials.

  • Product Name :

    3,4-Difluoro-2-methoxyphenylacetic acid CAS 1558274-26-2
  • CAS No. :

    1558274-26-2
  • Application :

    Suzetrigine/ VX-548 intermedaites
  • Description

3,4-Difluoro-2-methoxyphenylacetic acid (3,4-Difluoro-2-methoxyphenylacetic acid) is a white to off-white crystalline powder and a high-purity polysubstituted phenylacetic acid derivative. As a core building block in the synthetic route of next-generation “NaV1.8 inhibitors (such as VX-548/Suzetrigine)”, this product holds a strategically important position in the research and production of non-opioid analgesics. We employ proprietary fluorination and carboxylation synthesis technologies, strictly controlling isomers and related impurities in the product to ensure that we provide high-quality raw materials that meet registration requirements for global pharmaceutical companies and CDMOs.

 

Properties

- Appearance: Off-white solid

- Melting Point: 85-87 °C  

- Boiling Point: 286.5±35.0 °C 

- Density: 1.354±0.06 g/cm³

- Solubility: Soluble in methanol, ethyl acetate, and DMSO; slightly soluble in water.

- Storage temp:2-8°C

 

 

 

Specification

Items Specifications
Appearance Off-white solid
Purity 99%min
Loss On Drying ≤ 0.5%
The single biggest unknown impurity 0.3%

 

Applications

3,4-Difluoro-2-methoxyphenylacetic acid (CAS: 1558274-26-2) is a highly promising building block for drug molecules, primarily used in the field of innovative drug development.

  • Pharmaceutical Intermediates:

NaV1.8 inhibitor (Suzetrigine/VX-548) intermediate: This is currently the most important application direction for this product. It is a key structural unit in the synthesis of novel non-opioid analgesics Suzetrigine (VX-548) and its derivatives, used to construct the phenylacetic acid side chain backbone in the molecule. Such drugs are attracting much attention in the field of pain management due to their non-addictive nature.

 

  • Anti-tumor drug development:

It is used to synthesize specific inhibitors of signaling pathways that inhibit the excessive proliferation of tumor cells and is an important raw material for constructing fluorinated anticancer drug molecules.

 

  • Organic synthetic building blocks:

3,4-difluoro-2-methoxyphenyl group endows the molecule with unique electronic effects and metabolic stability, and is often used in structure-activity relationship studies during the lead optimization stage.

 

Package

  • #

Standard Packing:  25kg per fiber drum (lined with polyethylene bag)

 

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