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Ethyl 5-bromo-1 H-indole-2-carboxylate CAS:16732-70-0

Ethyl 5-bromo-1 H-indole-2-carboxylate CAS:16732-70-0

Ethyl 5-bromo-1H-indole-2-carboxylate, with CAS number 16732-70-0, is a high-purity indole derivative widely recognized as a critical intermediate in pharmaceutical synthesis and medicinal chemistry. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of pharmaceutical R&D and fine chemical industries.

  • Product Name :

    Ethyl 5-bromo-1 H-indole-2-carboxylate
  • CAS No. :

    16732-70-0
  • Application :

    Orforglipron intermediates
  • Description

Ethyl 5-bromo-1H-indole-2-carboxylate is a white to pale yellow crystalline powder and a chemically stable, high-purity indole derivative. As an important building block in organic synthesis and medicinal chemistry, this product plays an irreplaceable role in constructing complex bioactive molecules due to its specific substituent structure. Our optimized synthetic process ensures low impurity content and batch-to-batch quality stability, meeting various needs from laboratory research and development to industrial production.

 

Properties

Appearance​: Off-white solid

Melting point: 160-164 °C (lit.)

Boiling point:  423.8±25.0 °C(Predicted)

Density: 1.564±0.06 g/cm³ (estimate)

Storage temp: 2-8°C

Solubility: Soluble in organic solvents such as DMSO, dimethylformamide (DMF), and hot ethanol; insoluble in water.

 

 

Specification

Items Specifications
Appearance Off-white solid
Purity 100.0% (99.9902%)
Loss On Drying ≤0.5%
The single biggest unknown impurity 0.0% (0.0098%)
Residue on Ignition 0.0% (0.0218%)
Water Content 0.0% (0.0114%)

 

Applications

5-Phenylenol-2-benzoic acid ethyl ester (CAS: 16732-70-0) is a key intermediate in the synthesis of a variety of pharmaceutical active ingredients (API) and fine chemicals. Key applications include:​

 

  • Pharmaceutical Intermediates: Widely used in the research and synthesis of antiviral, antitumor, and cardiovascular disease drugs. Its 5-bromine atom provides an excellent functional group conversion site, facilitating the introduction of other groups through coupling reactions (such as Suzuki coupling), thereby constructing complex drug molecule skeletons.

 

  • Organic Synthesis: a general building block for synthesizing 2- and 5-disubstituted indole derivatives.

 

  • Biochemical research: Used to develop novel indole alkaloid analogs and study their structure-activity relationship (SAR).

 

 

 

Package

  • #
  • #

Standard Packing:  25kg per fiber drum (lined with polyethylene bag)

 

 

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