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Methyl 4-amino-2-pyridinecarboxylate CAS:71469-93-7

Methyl 4-amino-2-pyridinecarboxylate CAS:71469-93-7

Methyl 4-amino-2-pyridinecarboxylate, with CAS number 71469-93-7, is a high-purity pyridine derivative widely recognized as a critical intermediate in pharmaceutical synthesis (especially for anticancer drugs like Sorafenib). As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of global pharmaceutical R&D and API manufacturing industries.

  • Product Name :

    Methyl 4-amino-2-pyridinecarboxylate
  • CAS No. :

    71469-93-7
  • Application :

    Suzetrigine VX-548 intermediates
  • Description

Methyl 4-amino-2-pyridinecarboxylate is a high-purity pyridine pharmaceutical intermediate, appearing as a white to pale yellow crystalline powder. As a key backbone in the synthesis of multi-target kinase inhibitors, this product plays an irreplaceable role in the industrial production of anti-tumor drugs. We employ advanced chlorination and amination coupling processes to ensure low impurity levels (especially control over isomers), consistently meeting the stringent procurement standards of global pharmaceutical companies for GMP-grade or advanced intermediates.

 

Properties

- Appearance: OfT-white solid

- Melting Point: 104-108 °C 

- Boiling Point: 345.9±22.0 °C

- Storage temp:2-8°C

- Density: 1.282±0.06 g/cm³

- Solubility:Soluble in methanol, ethanol, and DMSO; slightly soluble in water.

 

 

Specification

Items Specifications
Appearance Off-white solid
Purity 99.0% min
Water ≤ 0.5%
The single biggest unknown impurity ≤ 0.5%
Total impurities ≤ 2%

 

Applications

4-Amino-2-pyridinecarboxylic acid methyl ester (CAS: 71469-93-7) is an extremely important pyridine building block in medicinal chemistry, especially widely used in the field of anticancer drugs.with key applications as follows:

 

  • Pharmaceutical Intermediates:

Sorafenib Key Intermediate: This is the core starting material for the synthesis of the anti-tumor drug sorafenib (trade name: Nexavar). Sorafenib is widely used to treat renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC).

Kinetic Inhibitor Development: Used in the synthesis of other novel VEGFR/PDGFR kinase inhibitors; its 4-amino and 2-ester group structure provides ample derivatization space for molecular modification.

  • Organic Synthesis:
    As a multifunctional building block for pyridine synthesis, it can undergo amidation, hydrolysis, or reduction reactions to construct more complex heterocyclic molecular libraries.

 

Package

  • #
  • #

Standard Packing:  25kg per fiber drum (lined with polyethylene bag)

 

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