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5-bromo-4-fluoro-1H-indazole CAS:1082041-85-7

Name: 5-bromo-4-fluoro-1H-indazole CAS:1082041-85-7
Availability: InStock

5-Bromo-4-fluoro-1H-indazole, with CAS:1082041-85-7, is a high-purity heterocyclic compound widely recognized as a critical intermediate in pharmaceutical synthesis. As a professional supplier, we adhere to strict quality control standards throughout the production process, ensuring our product meets the rigorous requirements of global drug discovery and API manufacturing.

Product Name :
5-bromo-4-fluoro-1H-indazole
CAS No. :
1082041-85-7
Application :
Orforglipron intermediates

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Description

5-Bromo-4-fluoro-1H-indole is a white to off-white crystalline powder, a high-purity heterocyclic organic building block. It plays a crucial role in medicinal chemistry as a core framework for the synthesis of next-generation small molecule drugs. We employ advanced synthetic routes and purification techniques, strictly controlling the content of isomers and impurities in our product to ensure a high-quality, batch-stable supply of raw materials for global pharmaceutical R&D institutions and commercial manufacturing companies.

Properties

Appearance： Light brown solid

Melting point: 165-169 °C(lit.)

Boiling point: 332.2±22.0 °C(Predicted)

Density： 1.86±0.1 g/cm³(estimate)

pKa: 11.5±0.4 (estimate)

Storage temp: 2-8°C

Solubility:Soluble in dimethyl sulfoxide (DMSO), methanol, and ethyl acetate; sparingly soluble in water.

Specification

Items	Specifications
Appearance	Light brown solid
Purity	99.9%
Loss On Drying	≤0.1%
Single Max Impurity	≤0.1%

Applications

5-Bromo-4-fluoro-1H-indole (CAS: 1082041-85-7) is a highly valuable pharmaceutical intermediate widely used in the discovery and development of innovative drugs.Key applications include:

Pharmaceutical Intermediates: A key starting material for the synthesis of GLP-1 receptor agonists (such as Orforglipron) and other drugs for metabolic diseases. Its unique 4-fluoro-5-bromo substitution mode provides precise reaction sites for subsequent molecular modifications.

Kinase Inhibitor Synthesis: Used to develop inhibitors targeting various kinases (such as Rho kinase), and widely used in the development of anti-tumor and cardiovascular drugs.

Organic Synthesis: The bromine atom at the 5-position can undergo coupling reactions such as Suzuki and Buchwald, and the nitrogen atom at the 1-position can undergo alkylation reactions (such as introducing methyl groups), making it a universal building block for constructing complex indole derivative libraries.

Package

Standard Packing: 25kg per fiber drum (lined with polyethylene bag)

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5-bromo-4-fluoro-1H-indazole CAS:1082041-85-7 high purity 99%

Orforglipron intermediates CAS:1082041-85-7

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