1,2-Ethanedithiol (CAS 540-63-6) is a high-purity organosulfur compound featuring two thiol (-SH) groups attached to an ethylene backbone, presented as a clear to pale green liquid.
With a high purity of 99.9% (GC), this versatile chemical serves as a critical building block in organic synthesis, metal coordination chemistry, and pharmaceutical manufacturing.
Engineered for consistency and reliability, our 1,2-Ethanedithiol meets the stringent quality requirements of research laboratories and industrial-scale production facilities worldwide, enabling precise and efficient synthetic processes across diverse applications.
Product Name :
1,2-EthanedithiolCAS No. :
540-63-6Application :
Lenacapavir intermediates1,2-Ethanedithiol (CAS 540-63-6) is produced under strict quality control protocols to ensure high purity 99.9% and low impurity levels, making it suitable for sensitive applications such as pharmaceutical API synthesis and advanced material research.
Properties
Product: 1,2-Ethanedithiol
CAS: 540-63-6
Molecular Formula:C₂H₆S₂
Molecular Weight:94.20 g/mol
Appearance:Clear to pale green liquid
Boiling Point:144-146 °C (lit.)
Melting Point:-41 °C (lit.)
Density:1.123 g/mL at 25 °C (lit.)
Solubility： Insoluble in water; miscible with ethanol, ether, acetone, and benzene
Specification
| Items | Specifications |
| Appearance | Colorless clear liquid |
| Purity | 99.9%min |
Applications
1,2-Ethanedithiol is a multifunctional reagent with broad utility in organic synthesis, pharmaceutical manufacturing, and material science, leveraging its unique thiol reactivity and bidentate ligand properties. Key applications include:
1. Pharmaceutical API Synthesis (Lenacapavir Production): A critical application of 1,2-Ethanedithiol is as a thioacetal protecting reagent in the synthesis of Lenacapavir (Sunlenca®), a potent HIV-1 capsid inhibitor. During the API manufacturing process, it reacts with active double bonds in key bicyclic pyrazole carboxylic acid intermediates (under catalysis by p-toluenesulfonic acid, p-TsOH, in acetic acid) to form stable thioacetal structures. This protection prevents unwanted side reactions (e.g., addition, polymerization, oxidation) during subsequent high-activity steps such as fluorination (e.g., with HF·py systems). The thioacetal group can be efficiently deprotected via acidic hydrolysis (p-TsOH/MEK-H₂O) later in the synthesis, ensuring the integrity of the target molecular skeleton. This protection-deprotection strategy contributes to high process yields (≥80% for the two-step sequence) and scalability, making it indispensable for large-scale Lenacapavir production.
2. Organic Synthesis & Heterocycle Formation: Widely used to synthesize 1,3-dithiolanes via condensation reactions with aldehydes or ketones, serving as valuable intermediates for the construction of complex organic molecules. It also enables the synthesis of dithiazepan-3-yl-alkanoic acids through cyclocondensation with amino acids and formaldehyde, supporting drug discovery and fine chemical development.
3. Metal Coordination Chemistry: Acts as a bidentate ligand, forming stable chelate complexes with various metal ions (e.g., transition metals). These complexes are utilized in catalysis, material science, and the development of metal-based catalysts for industrial chemical processes.
4. Peptide Synthesis & Deprotection: Serves as an efficient scavenger in solid-phase peptide synthesis (SPPS), facilitating the deprotection of peptide resins by removing reactive byproducts and ensuring the purity of final peptide products.
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