Methyl 2,3,4-trifluorobenzoate is a high-purity fluorinated ester derivative. It serves as a versatile alternative to 2,3,4-trifluorobenzoic acid in the synthesis of fluoroquinolone antibiotics (e.g., Ofloxacin, Levofloxacin), offering superior reactivity in specific condensation steps. As a professional supplier, we guarantee low acid value and moisture content, ensuring optimal performance in your synthesis processes.
Product Name :
Methyl 2,3,4-trifluorobenzoateCAS No. :
773873-68-0Application :
Suzetrigine/ VX-548 intermedaitesProperties
- Physical State: Colorless liquid
- Density: 1.385±0.05 g/cm³
- Boiling Point: 198-200 °C
- Refractive index:1.455
- Solubility: Miscible with organic solvents such as ethanol, diethyl ether, and ethyl acetate; insoluble in water.
- Storage temp: Store at room temperature; sealing and keeping dry are recommended.
Specification
| Items | Specifications |
| Appearance | Colorless liquid |
| Purity | 99.9%min |
Applications
- Pharmaceutical Industry:
Key raw material for quinolone antibiotics: Like its free acid form, methyl ester is mainly used in the synthesis of third-generation fluoroquinolone antibiotics, such as ofloxacin and levofloxacin.
Reaction advantages: In some synthetic routes, the methyl ester form can be used directly with ethyl acetate or diethyl malonate in a Claisen condensation reaction to construct the β-keto ester skeleton required for the quinolone core, with milder reaction conditions and higher yields.
- Organic Synthesis: As a highly efficient 2,3,4-trifluorobenzoyl group donor, it is used to introduce fluorinated aromatic ring structures into complex molecules.
DUDLEY is your trusted partner for high-quality organic intermediates and custom synthesis solutions.
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