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Methyl 2,3,4-trifluorobenzoate CAS:773873-68-0

Methyl 2,3,4-trifluorobenzoate CAS:773873-68-0

Methyl 2,3,4-trifluorobenzoate is a high-purity fluorinated ester derivative. It serves as a versatile alternative to 2,3,4-trifluorobenzoic acid in the synthesis of fluoroquinolone antibiotics (e.g., Ofloxacin, Levofloxacin), offering superior reactivity in specific condensation steps. As a professional supplier, we guarantee low acid value and moisture content, ensuring optimal performance in your synthesis processes.

  • Product Name :

    Methyl 2,3,4-trifluorobenzoate
  • CAS No. :

    773873-68-0
  • Application :

    Suzetrigine/ VX-548 intermedaites
  • Description
Our methyl 2,3,4-trifluorobenzoate is a colorless, transparent liquid and a high-purity fluorinated aromatic ester intermediate. It is a crucial starting material for the synthesis of fluoroquinolone antibacterial drugs (such as ofloxacin and levofloxacin). We employ advanced continuous esterification and distillation purification processes to effectively control acid value and moisture content, ensuring extremely high purity (GC ≥ 99%) and excellent reactivity, meeting the stringent requirements of downstream pharmaceutical synthesis processes for anhydrous and low-acid feedstocks.

Properties

- Physical State:  Colorless liquid

- Density: 1.385±0.05 g/cm³

- Boiling Point: 198-200 °C

- Refractive index:1.455

- Solubility: Miscible with organic solvents such as ethanol, diethyl ether, and ethyl acetate; insoluble in water.

- Storage temp: Store at room temperature; sealing and keeping dry are recommended.

 

Specification

Items Specifications
Appearance Colorless liquid
Purity 99.9%min

 

Applications

- Pharmaceutical Industry:

Key raw material for quinolone antibiotics: Like its free acid form, methyl ester is mainly used in the synthesis of third-generation fluoroquinolone antibiotics, such as ofloxacin and levofloxacin.

Reaction advantages: In some synthetic routes, the methyl ester form can be used directly with ethyl acetate or diethyl malonate in a Claisen condensation reaction to construct the β-keto ester skeleton required for the quinolone core, with milder reaction conditions and higher yields.

 

Organic Synthesis: As a highly efficient 2,3,4-trifluorobenzoyl group donor, it is used to introduce fluorinated aromatic ring structures into complex molecules.

DUDLEY is your trusted partner for high-quality organic intermediates and custom synthesis solutions.

 

 

Package

Packaging & Storage:25kg/iron drum

 

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