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3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide CAS:131988-19-7

3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide CAS:131988-19-7

3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide, with CAS number 131988-19-7, is a high-purity quaternary ammonium salt. It serves as the direct precursor for the synthesis of Xanomeline (the active ingredient of the blockbuster drug KarXT/Cobenfy). As a professional supplier, we offer this advanced intermediate with exceptional purity (≥99.0%), enabling pharmaceutical manufacturers to streamline their API production process with high yield and quality assurance.

  • Product Name :

    3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide
  • CAS No. :

    131988-19-7
  • Application :

    Xanomeline Intermediates
  • Description

Dudley's 3-(4-hexyloxy-1,2,5-Thiadiazol-3-yl)-1-methylpyridine iodide is a bright yellow crystalline powder and a high-purity quaternary ammonium salt pharmaceutical intermediate. As a direct precursor for the synthesis of the M1/M4 muscarinic receptor agonist xanomeline, this product plays a central role in the production chain of drugs for schizophrenia and Alzheimer's disease. We employ a precise quaternization process, strictly controlling the reaction endpoint to ensure extremely high conversion rates and purity, yielding a high-quality active pharmaceutical ingredient (API) in a single reduction step

 

Properties

- Appearance: Yellow solid

- Melting Point: 160-165 °C  

- Boiling Point: 286.5±35.0 °C 

- Molecular Weight: 405.30 g/mol

- Solubility: Soluble in methanol, ethanol, and DMSO; slightly soluble in ethyl acetate.

- Storage temp:2-8°C,Store in a dark place

 

 

Specification

Items Specifications
Appearance Yellow solid
Purity 99.88%min
Water ≤ 0.02%
The single biggest unknown impurity 0.07%

 

Applications

3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridine iodide (CAS: 131988-19-7) is the highest-order intermediate in the Xanomeline synthetic route.

  • Xanomeline Direct Precursor:

 

This product can be directly converted into Xanomeline (the active ingredient of KarXT/Cobenfy) by selective reduction with sodium borohydride (NaBH4) or other reducing agents.

 

As it is the final intermediate step before the active pharmaceutical ingredient (API), its purity directly determines the impurity profile of the final API. Therefore, high-end pharmaceutical companies have extremely stringent quality requirements for this product.

 

  • Medicinal chemistry research:

It can be used to develop other quaternary ammonium salt derivatives targeting muscarinic receptors or as a cationic probe tool.

 

Package

  • #

Standard Packing:  25kg per fiber drum (Black blackout inner bag)

 

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